Application notes

Omic technologies arise as useful tools in obesity research. Due to its high metabolic activity and its ability of secretion, adipose tissue is no longer considered as a passive energy keeper but as a critical component in the regulation of energy balance. The Obesity Research Laboratory at the institute of Molecular Medecine (INSERM-Paul Sabatier University) in Toulouse (Dr. Nathalie Viguerie, Pr. Dominique Langin) uses gene expression microarrays for deciphering adipose tissue transcriptome modifications face to nutritional challenges such as low calorie diets and other clinical investigation protocols...

For higher density arrays, (approximately 13 μm spot size), fluorescent signal from 3 μm resolution scanning typically provides 16 pixels per feature which translates to improved confidence in the resulting data and increased number of reference CNVs detected when compared to 5 μm resolution scanning. When scanning the same arrays at 2 μm resolution, at least 36 pixels per feature are generated; which greatly enhances the fluorescent data leading to more accurate calls and increased confidence in the final examination and reporting of chromosomal aberrations...