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Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray

Identification of Adipophilin as a Potential Plasma Biomarker for Colorectal Cancer Using Label-Free Quantitative Mass Spectrometry and Protein Microarray 

Junichi Matsubara1,6, Kasufumi Honda1, Masaya Ono1, Shigeki Sekine 2, Yoshinori Tanaka7, Michomoto Kobayashi7, Giman Jung7, Tomohiro Sakuma3, Shoji Nakamori8, Naohiro Sata11, Hideo Nagai11, Tasuya loka9, Takuji Okusaka4, Tomoo Kosuge4, Akihiko Tsuchida5, Masashi Shimahara10, Yohichi Yasunami12, Tsutomu Chiba6, and Tesshi Yamada1. 
1. Division of Chemotherapy and Clinical Research, National Cancer Center Research Institute, Japan
2. Division of Molecular Pathology, National Cancer Center Research Institute, Japan
3. BioBusiness Group, Mitsui Knowledge Industry
4. Hepatobiliary and Pancreatic Oncology and Hepatobiliary and Pancreatic Surgery Divisions, National Cancer Center Hospital, Japan
5. Third Department of Surgery, Tokyo Medical University, Tokyo, Japan
6. Department of Gastroenterology and Hepatology; Kyoto University Graduate School of Medicine, Kyoto, Japan
7. New Frontiers Research Laboratories, Toray Industries, Kamakura
8. Department of Surgery, Osaka National Hospital, National Hospital Organization, Japan
9. Department of Hepatobiliary and Pancreatic Oncology, Osaka Medical Center for Cancer and Cardiovascular Diseases, Japan
10. Department of Oral Surgery, Osaka Medical College, Osaka, Japan
11. Department of Surgery, Jichi Medical University, Shimotsuke, Japan
12. Department of Regenerative Medicine and Transplantation, Fukuoka University Faculty of Medicine, Fukuoka, Japan 

Abstract

Background: The aim of this study was to identify a new plasma biomarker for use in early detection of colorectal cancer.

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