lifesciences
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ACTN3 R577X polymorphism and team-sport performance: A study involving three European cohorts

Abstract:

OBJECTIVES:

To determine the association between the α-actinin-3 (ACTN3) R577X polymorphism and elite team-sport athletic status in three cohorts of European team-sport athletes.

DESIGN:

We compared the genotype and allele frequencies of the ACTN3 R577X (rs1815739) polymorphisms between team-sport athletes (n=205), endurance athletes (n=305), sprint/power athletes (n=378), and non-athletic controls (n=568) from Poland, Russia and Spain; all participants were unrelated European men.

METHODS:

Genomic DNA was extracted from either buccal epithelium or peripheral blood using a standard protocol. Genotyping was performed using several methods, and the results were replicated following recent recommendations for genotype-phenotype association studies.

RESULTS:

Genotype distributions of all control and athletic groups met Hardy-Weinberg equilibrium (all p>0.05). Team-sport athletes were less likely to have the 577RR genotype compared to the 577XX genotype than sprint/power athletes [odds ratio: 0.58, 95% confidence interval: 0.34-0.39, p=0.045]. However, the ACTN3 R577X polymorphism was not associated with team-sports athletic status, compared to endurance athletes and non-athletic controls. Furthermore, no association was observed for any of the genotypes with respect to the level of competition (elite vs. national level).

CONCLUSIONS:

The ACTN3 R577X polymorphism was not associated with team-sport athletic status, compared to endurance athletes and non-athletic controls, and the observation that the 577RR genotype is overrepresented in power/sprint athletes compared with team-sport athletes needs to be confirmed in future studies.

Credits:

Eynon N1, Banting LK2, Ruiz JR3, Cieszczyk P4, Dyatlov DA5, Maciejewska-Karlowska A6, Sawczuk M6, Pushkarev VP5, Kulikov LM5, Pushkarev ED5, Femia P7, Stepto NK8, Bishop DJ8, Lucia A9.

  • 1. School of Sport and Exercise Sciences, Victoria University, Australia; Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Australia.
  • 2. Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Australia.
  • 3. Department of Physical Education and Sport, School of Sport Sciences, University of Granada, Spain.
  • 4. Department of Tourism and Recreation, Academy of Physical Education and Sport in Gdansk, Poland.
  • 5. Ural State University of Physical Culture, Russia.
  • 6. Department of Physical Culture and Health Promotion, University of Szczecin, Poland.
  • 7. Department of Biostatistics, School of Medicine, University of Granada, Spain.
  • 8. School of Sport and Exercise Sciences, Victoria University, Australia; Institute of Sport, Exercise and Active Living (ISEAL), Victoria University, Australia.
  • 9. Universidad Europea de Madrid, Spain.

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