Array CGH analysis shows that aneuploidy is not related to the number of embryos generated


This study retrospectively analysed array comparative genomic hybridization (CGH) results of 7753 embryos from 990 patients to determine the frequency of embryonic euploidy and its relationship with the cohort size (i.e. the number of embryos available for biopsy and array CGH analysis). Linear regression analysis was performed to assess the effect of cohort size on euploidy rate adjusted for the effect of female age. While increasing female age was associated with a significant decrease in euploidy rate of day-3 and day-5 embryos (P<0.001 for both groups), cohort size was not significantly associated with euploidy rate. Logistic regression analysis was performed to assess the effect of cohort size, adjusted for maternal age, on the likelihood of having at least one euploid embryo available for transfer. The odds of having at least one euploid embryo in an assisted cycle was significantly decreased by increasing female age (P<0.01 for both day-3 and day-5 embryos) and was significantly increased by every additional embryo available for analysis (P<0.001 for both day-3 and day-5 embryos).


Ata Ba,b, Kaplan Bc, Danzer Hd, Glassner Me, Opsahl Mf, Tan SLa,g, Munné Sh.

  • a. MUHC Reproductive Center, Div. Of Reproductive Endocrinology and Infertility, Dept. of Obstetrics and Gynecology, McGill University, Montreal, Canada H3A 1A1
  • b. Assisted Reproduction Unit, Dept. Of Obstetrics and Gynecology, Uludag University, Gorukle, Bursa, 16059, Turkey
  • c. Fertility Centers of Illinois, 767 Park Ave. suite B400, Highland Park, IL 60035 USA
  • d. ART Reproductive Center, 450 North Roxbury Drive Suite 500 Beverly Hills, CA 90210, USA
  • e. Main Line Fertility and Reproductive Medicine, 130 South Bryn Mawr Ave. Ground Fl D Wing Bryn Mawr, PA 19010, USA
  • f. Northwest Center for Reproductive Sciences, 1233 NE 130th Lane Suite 220Kirkland, WA 98034, USA
  • g. Montreal Reproductive Center, 2110 Boulevard Decaire, Montreal, Canada H4A 3J3
  • h. Reprogenetics, Livingston, NJ 0703, USA


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