lifesciences
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The -174 G/C polymorphism of the IL6 gene is associated with elite power performance

Abstract:

The -174 G/C polymorphism [rs1800795] of the IL6 gene is a candidate to explain individual variations in health and exercise related phenotypes. We compared -174 G/C genotypic and allelic frequencies in three groups of men of the same Caucasian (Spanish) descent: elite endurance athletes (cyclists, runners; n=100); elite power athletes (jumpers, throwers, sprinters; n=53) and non-athletic controls (n=100). The frequency of the GG genotype (P=0.030) and G allele (P=0.026) was higher in the power athletes group compared with the control group. The frequency of the GG genotype (P=0.033) and G allele (P=0.013) was also higher in the power athletes group compared with the endurance athletes group. The odds ratio of being a power athlete if the subject had the GG genotype (dominant model) was 2.471 (95% confidence interval: 1.242-4.915) compared to the control group or the endurance athlete group. We did not find differences between the control and endurance athlete groups. In summary, our findings suggest that the G allele of the IL6 -174 G/C polymorphism might favour sprint/power sports performance.

Credits:

Ruiz JRa, Buxens Ab, Artieda Mb, Arteta Db, Santiago Cc, Rodríguez-Romo Gd, Lao JIe, Gómez-Gallego Fc, Lucia Ac.

  • a. Department of Biosciences and Nutrition, Unit for Preventive Nutrition, Karolinska Institutet, Stockholm, Sweden
  • b. Progenika Biopharma, Parque Technologico de Zamudio, Deri-Vizcaya, Spain
  • c. Universidad Europea de Madrid, Spain
  • d. INEF, Universidad Politécnica de Madrid, Spain
  • e. Sabiobbi S.I., Spain

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