lifesciences
Innopsys

Live birth from a patient with a three-way balanced translocation t(5,8,12)

Abstract:

Background:

Three-way balanced translocations are unusual and can lead to infertility as well as abnormal embryos. In this case report we describe a couple that experienced repeated miscarriages due to the male partner being a carrier of a three-way translocation t(5, 8, 12) .

Objectives:

Array comparative genomic hybridization (array-CGH) was used to screen embryos for chromosome imbalances.

Methods:

Embryo biopsy, preimplantation genetics diagnosis (PGD) using 24Sure+ kit to detect translocations in embryos.

Results:

Out of 10 embryos tested, 2 were found to be unbalanced translocation carriers, 4 were aneuploid, 2 failed to amplify and 2 were euploid. Transfer of 2 euploid embryos resulted in a singleton pregnancy and subsequently a birth of a baby.

Conclusion:

Array-CGH in conjunction with 24Sure+ kit should be used as a routine screening method for embryos of balanced translocation carriers as it can decrease the time to pregnancy and prevent repeated miscarriages.

Credits:

Anil Ramdeo, Kinnon Naidoo, Teresa Ernest, Katarzyna Pluta.

  • C.A.R.E. Clinic (Centre for Assisted Reproduction and Endocrinology), Westville, Durban, South Africa

HEAD OFFICE

Parc d'activités Activestre
31390 Carbonne - FRANCE

CONTACT

Phone +33 561 971 974
Fax +33 561 971 975