lifesciences
Innopsys

Feasibility of preimplantation genetic diagnosis for hereditary breast and ovarian cancer: report on a large cohort study

SESSION 51: PGD/PGS: LOOK TO THE PAST, PREPARE THE FUTURE

Hum. Reprod. (2012) 27 (suppl 2): ii74-ii76. This article appears in: Abstract book of the 28th ESHIRE Annual Meeting, Turkey 1 July – 4 July 2012
doi: 10.1093/humrep/27.s2.50

Abstract:

Introduction: Female carriers of a mutation in the BRCA1 or BRCA2 genes (BRCA1/2) have a lifetime risk of 60-80% to develop breast cancer and a risk of 30-60% (BRCA1) or 5-20% (BRCA2) for ovarian cancer. The late onset, reduced penetrance and availability of preventive and therapeutic options of this autosomal dominant disorder make prenatal diagnosis (PND) for BRCA1/2 controversial. Preimplantation genetic diagnosis (PGD) offers a reproductive alternative. Up to now only three reports have described a total of five pregnancies after PGD for BRCA1/2. The safety of hormonal stimulation needed for IVF/PGD treatment in female BRCA1/2 carriers has not been systematically studied so far.

Credits:

I.A.P. Derks-Smeets1, W. Verpoest2, S. Mackens2, P. Verdyck3, G. Verheyen2, A. Paulussen1, J. Dreesen1, R. Van Golde4, V.C.G. Tjan-Heijnen5, M. Meijer-Hoogeveen6, E.B. Gómez García1, J. De Greve7, M. Bonduelle3, C.E.M. De Die-Smulders1 and M. De Rycke3

  • 1 Maastricht University Medical Centre, Department of Clinical Genetics, Maastricht, The Netherlands
  • 2 Universitair Ziekenhuis Brussel, Centre for Reproductive Medicine, Brussels, Belgium
  • 3 Universitair Ziekenhuis Brussel, Centre for Medical Genetics, Brussels, Belgium
  • 4 Maastricht University Medical Centre, Department of Obstetrics and Gynecology, Maastricht, The Netherlands
  • 5 Maastricht University Medical Centre, Department of Internal Medicine, Division of Medical Oncology
  • 6 University Medical Centre Utrecht, Department of Reproductive Medicine and Gynecology, Utrecht, The Netherlands
  • 7 Universitair Ziekenhuis Brussel, Department of Medical Oncology, Brussels, Belgium

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