Automation in an Array Comparative Genomic Hybridization Laboratory Improves Throughput and Data Quality

Seth M. Taapken,* Benjamin S. Nisler, Tori L. Sampsell-Barron, and Karen Dyer Montgomery
WiCell Cytogenetics Laboratory, WiCell Research Institute, Madison, WI


Array-based comparative genomic hybridization is rapidly becoming a standard assay for research and clinical cytogenetics laboratories. Certain automated workflows are used to achieve economies in running this relatively expensive assay. Here, we describe the ways in which our medium throughput laboratory has investigated automation at various points in our workflow to achieve economies and improve the resulting data for our investigators. We investigate an automated hybridization station to improve microarray hybridization, an autoloading scanner to facilitate the rapid scanning of multiple arrays, and a software package that allows for quick and easy access to many external resources to extend the analysis.


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