Alteration of gene expression in human cumulus cells as a potential indicator of oocyte aneuplody

E. Fragouli1,2, D.Wells1,2, A.E. Iager3, U.A. Kayisli4 and P. Patrizio4
1. Nuffield Department of Obstetrics and Gynaecology, University of Oxford, Oxford OX3 9DU, UK
2. Reprogenetics UK, Oxford OX4 2HW, UK 
3. Gema Diagnostics, Ann Arbor, MI 48104, USA 
4. Department of Obstetrics, Gynecology, Reproductive Sciences, Yale University School of Medicine, New Haven, CT 06510, USA  


BACKGROUND Human female meiosis is particularly error prone, leading to the generation of aneuploidy, a problem which increases dramatically with advancing age. Despite being of great clinical importance, the genesis of oocyte aneuploidy remains poorly understood. Cumulus cells (CCs) surround oocytes in antral follicles and play a crucial role in regulating their maturation. During this investigation, we aimed to obtain an insight into the follicular environment of oocytes that become aneuploid and identify non-invasive markers of oocyte chromosome status and competence.


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