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Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake

Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake

Adriana Ma ´rquez-Quin ˜ones, David M Mutch, Cyrille Debard, Ping Wang, Marion Combes, Balbine Roussel, Claus Holst, J Alfredo Martinez, Teodora Handjieva-Darlenska, Pavla Kalouskova, Susan Jebb, Dimitris Babalis, Andreas FH Pfeiffer, Thomas M Larsen, Arne Astrup, Wim HM Saris, Edwin Mariman, Karine Cle ´ment, Hubert Vidal, Dominique Langin, and Nathalie Viguerie on behalf of the DiOGenes Project

ABSTRACT

Background: The mechanisms underlying body weight evolution after diet-induced weight loss are poorly understood.
Objective: We aimed to identify and characterize differences in the subcutaneous adipose tissue (SAT) transcriptome of subjects with different weight changes after energy restriction–induced weight loss during 6 mo on 4 different diets.
Design: After an 8-wk low-calorie diet (800 kcal/d), we randomly assigned weight-reduced obese subjects from 8 European countries to receive 4 diets that differed in protein and glycemic index content. In addition to anthropometric and plasma markers, SAT biopsies were taken at the beginning [clinical investigation day (CID) 2] and end (CID3) of the weight follow-up period. Microarray analysis was used to define SAT gene expression profiles at CID2 and CID3 in 22 women with continued weight loss (successful group) and in 22 women with weight regain (unsuccessful group) across the 4 dietary arms.

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