Genome profiling of ovarian adenocarcinomas using pangenomic BACs microarray comparative genomic hybridization

Donatella Caserta*1, Moncef Benkhalifa2, Marina Baldi3, Francesco Fiorentino3, Mazin Qumsiyeh2,4 and Massimo Moscarini1

Address: 1Oby/Gyn Dept. Saint Andrea Hospital, University of Roma La Sapienza, Rome, italy, 2Genetics & IVF, A TL R&D Laboratory, La Verrière
france & UNILABS Laboratories, Geneva, Switzerland, 3Molecular Biology & Cytogenetics, Genoma Laboratories, Rome, italy and 4Cytogenetics
Laboratory, SiParadigm Laboratories, 690 Kinderkamack Rd, Oradell, NJ, USA
Email: Donatella Caserta* -; Moncef Benkhalifa -;
Marina Baldi -; Francesco Fiorentino -;
Mazin Qumsiyeh -; Massimo Moscarini -
* Corresponding author


Background: Routine cytogenetic investigations for ovarian cancers are limited by culture failure
and poor growth of cancer cells compared to normal cells. Fluorescence in situ Hybridization (FISH)
application or classical comparative genome hybridization techniques are also have their own
limitations in detecting genome imbalance especially for small changes that are not known ahead of
time and for which FISH probes could not be thus designed.


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