Bifidobacterium bifidum PRL2010 Modulates the Host Innate Immune Response


Here, we describe data obtained from transcriptome profiling of human cell lines and intestinal cells of a murine model upon exposure and colonization, respectively, with Bifidobacterium bifidum PRL2010. Significant changes were detected in the transcription of genes that are known to be involved in innate immunity. Furthermore, results from enzyme-linked immunosorbent assays (ELISAs) showed that exposure to B. bifidum PRL2010 causes enhanced production of interleukin 6 (IL-6) and IL-8 cytokines, presumably through NF-κB activation. The obtained global transcription profiles strongly suggest that Bifidobacterium bifidum PRL2010 modulates the innate immune response of the host.


Francesca Turronia, Valentina Tavernitib, Patricia Ruas-Madiedoc, Sabrina Durantid, Simone Guglielmettib, Gabrielle Andreea Luglid, Laura Gioiosae, Paola Palanzae, Abelardo Margollesc, Douwe van Sinderena and Marco Venturac

  • a. Alimentary Pharmabiotic Centre and Department of Microbiology, Bioscience Institute, National University of Ireland, Cork, Ireland
  • b. Dipartimento di Scienze e Tecnologie Alimentari e Microbiologiche, Universtità degli Studi di Milano, Milan, Italy
  • c. Departamento de microbiologia y Bioquimica de Productos Lacteos (IPLA-CSIC), Villaviciosa, Asturias, Spain
  • d. Laboratory of Probiogenomics, Department of Life Sciences, University of Parma, Parma, Italy
  • e. Department of Evolutionary and Functional Biology, University of Parma, Parma, Italy


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