Proteins are considered to be the key effectors of cellular response to external stimuli.

Differential expression of key proteins can modulate cell fate, either cell differentiation, proliferation or death. Protein microarrays are a powerful tool for high-throughput screening of protein expression due to their capacity to miniaturize thousands of single points of analysis.

High-throughput screening requires of highly precise detection systems to increase assay sensitivity and dynamic range. The InnoScan scanners allow for the detection of heterogeneous samples with weak and strong protein levels simultaneously.

Multiplexing is achieved through the detection of two (InnoScan 710 & 710-IR) or three (InnoScan 1100) fluorophores simultaneously, while the resolution and dynamic range are adapted for any type of protein array, either functional, analytical and reverse phase protein arrays.

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Different type of protein arrays for which InnoScan scanners are compatible
Different type of protein arrays for which InnoScan scanners are compatible

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Normandeau F, et al. Spatial bias in antibody microarrays may be an underappreciated source of variability. ACS Sens. 2021; 6(5): 1796-1806

2020 -- USA
Chen F, Nagy K, et al. 2020. Antibody Responses to Immunization With HCV Envelope Glycoproteins as a Baseline for B cell-Based Vaccine Development, Gastroenterology

2018 -- USA
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2017 -- USA
Phillips B, Fouda GG, et al. 2017. Impactof poxvirus vector priming, proteincoadministration, and vaccine intervals on HIVgp120 vaccine-elicited antibody magnitudeand function in infant macaques. Clin VaccineImmunol 24:e00231-17.

2019 -- South Korea
Han J-H, Cheng Y, et al. 2019. Inhibition of parasite invasion by monoclonal antibody against epidermal growth factor-like domain of Plasmodium vivax merozoite surface protein 1 paralog. Scientific Reports. 9(1):3906

2017 -- South Korea
Cheng Y, Wang B, et al. 2017. Naturally acquired humoral and cellular immune responses to Plasmodium vivax merozoite surface protein 8 in patients with P. vivax infection. Malaria Journal. 16(1):211.

2016 -- USA
McBride R, Head SR, et al. 2016. Low-Cost Peptide Microarrays for Mapping Continuous Antibody Epitopes. In: Cretich M., Chiari M. (eds) Peptide Microarrays. Methods in Molecular Biology, vol 1352. Humana Press, New York, NY.

2020 -- China
Han Xian-Kui, Wang Hui-Fang, et al. 2020. P38 Inhibition Prevents Herpes Simplex Virus Type 1 (HSV-1) Infection in Cultured Corneal Keratocytes, Current Eye Research.

2019 -- Russia
Plotnikova M, Klotchenko SA, et al. 2019. Antibody microarray immunoassay for screening and differential diagnosis of upper respiratory tract viral pathogens. J Immunol Methods 478:112712.