Influenza B Research: Microarrays and Innoscan scanner Reveal Key Immune Insights
Discover an Innoscan application about influenza B research using microarrays. A recent study published in Science Advances unveils the critical role of neuraminidase (NA)-specific antibodies in cross-protection between influenza B virus (FLUBV) lineages. Using antigen microarrays, researchers mapped antibody responses to diverse influenza strains, revealing that Victoria-lineage infections elicit broad, cross-reactive NA antibodies, unlike Yamagata-lineage infections. The InnoScan 1100 AL laser scanner enabled high-throughput profiling of serum IgG/IgA binding to recombinant HA and NA proteins, confirming functional disparities in antibody reactivity. This work underscores the potential of NA-targeted vaccines and the utility of microarray and InnoScan in dissecting humoral immunity.
Keywords: Influenza B, neuraminidase, cross-protection, antigen microarray, InnoScan micrroarray scanner, Influenza B Research: Microarrays
Original publication: Neuraminidase-specific antibodies drive differential cross-protection between contemporary FLUBV lineages | Science Advances
Learn more about the InnoScan microarray scanner series: InnoScan Microarray Scanners – Innopsys