InnoScan microarray scanner: new publication
Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells
Discover a use case in the latest publication using our InnoScan microarray scanner. In a recent study published in Cell Metabolism, researchers found that exosomal miR-302b derived from human embryonic stem cells (hESC-Exos) can rejuvenate aging mice by reversing the proliferative arrest of senescent cells (SnCs). miR-302b is identified as a key molecule targeting the cell cycle inhibitors Cdkn1a and Ccng2, restoring cell proliferation and improving lifespan, physical performance, and cognitive function in aged mice without increasing tumor risk. A critical tool in this research was the InnoScan Microarray Scanner, used to analyze cytokine arrays in mouse serum. This high-precision instrument enabled the team to quantify pro-inflammatory cytokines, confirming that miR-302b delivery significantly reduced age-related chronic inflammation. The findings propose a novel “Senoreverse” strategy, offering promising avenues for anti-aging therapies.
Keywords:
- Exosomal miR-302b
- Cellular senescence
- Anti-aging
- Senoreverse strategy
Original publication: Exosomal miR-302b rejuvenates aging mice by reversing the proliferative arrest of senescent cells: Cell Metabolism
Learn more about the InnoScan series: InnoScan Microarray Scanners – Innopsys