InnoScan microarray scanner: new publication

Use of a small molecule microarray screen to identify inhibitors of the catalituc RNA subunit of Methanobrevibacter smithii RNase P

Read about a use case of Small Molecule microarray scanner. The study explores the use of small molecule microarrays (SMM) to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P (Msm RPR), a large ribozyme involved in tRNA maturation. The researchers employed an SMM screen of 7,300 compounds, identifying 48 hits that specifically bound to Msm RPR. The study utilized the InnoScan 1100 AL fluorescence scanner to image the microarrays, which allowed for high-resolution detection of fluorescence signals to identify small molecule binders. Structure-activity relationship (SAR) analysis of M1 analogs provided insights into the functional groups essential for inhibition. The findings highlight the potential of SMM screens for advancing RNA druggability by identifying new privileged scaffolds / chemotypes that bind large structured RNAs.

Keywords:

1. Small molecule microarray
2. RNA-targeted
3. Drug Discovery
4. Innoscan micraoarray scanner
5. Small Molecule microarray scanner

Original publication:Use of a small molecule microarray screen to identify inhibitors of the catalytic RNA subunit of Methanobrevibacter smithii RNase P

Learn more about the InnoScan series: InnoScan Microarray Scanners – Innopsys